Cytomegalovirus Infection in Native Kidney Biopsy A Rare Clinical Insight

Introduction

Cytomegalovirus (CMV) infections are commonly associated with renal transplant cases, but their occurrence in native kidneys remains rare. This article explores a case of CMV infection in a native kidney biopsy, shedding light on its clinical implications and diagnosis. For more groundbreaking research in nephrology, visit HSPIOA.

Case Overview

A 61-year-old woman with a history of thymoma resection presented with proteinuria detected during routine screening. Despite normal glucose and lipid levels, laboratory tests showed proteinuria (2.43 g/day) and a low serum albumin level (2.4 g/dl). Further investigations ruled out autoimmune diseases and common infectious causes.

Clinical Findings

• Renal Biopsy Results:
  • Focal Segmental Glomerulosclerosis (FSGS) detected.
  • Presence of nuclear and cytoplasmic viral inclusions characteristic of CMV.
  • Immunohistochemistry confirmed CMV infection in renal tissue.
• Additional Diagnostics:
  • Positive CMV serum PCR (low titers).
  • Gastric ulcer biopsies also showed CMV involvement.

Broader Implications of CMV in Renal Disease

CMV is a well-documented secondary cause of FSGS, primarily reported in renal grafts. However, its presence in native kidneys highlights the importance of considering CMV in patients with primary immunodeficiency and unexplained proteinuria.

According to the National Kidney Foundation (NKF), early diagnosis and management of viral-associated glomerular diseases are critical to preserving renal function.

Further Reading and Resources

• DOI Reference: Read the full study at https://doi.org/10.29328/journal.jcn.1001047.
• Further Reading: Explore more nephrology-related studies on our journal homepage.

Conclusion and Call-to-Action

This case emphasizes the need for heightened awareness of CMV as a potential contributor to native kidney disease. Early detection through biopsy and PCR testing can guide appropriate clinical management.

Stay updated with the latest nephrology research by visiting HSPIOA and share your thoughts in the comments below!

Disclaimer: This content is generated using AI assistance and should be reviewed for accuracy and compliance before considering this article and its contents as a reference.Any mishaps or grievances raised due to the reusing of this material will not be handled by the author of this article.