Zinc Supplementation Reduces Oxidative Stress in Hemodialysis Patients A Clinical Study

Introduction

Patients undergoing maintenance hemodialysis (HD) often experience increased oxidative stress, contributing to higher cardiovascular disease risks. Zinc (Zn), a key antioxidant, has been linked to improved oxidative balance, but its supplementation in HD patients remains underexplored. A recent study published in the Journal of Clinical Nephrology examined the effects of Zn supplementation on oxidative stress markers, offering new perspectives on its potential benefits.

Key Findings of the Study

Researchers conducted a randomized, single-blind clinical trial involving 77 hemodialysis patients, with 37 completing the study. Participants were divided into two groups:
Zn-supplemented group (received 220 mg Zn sulfate daily for two months)
Placebo group (received 220 mg maltodextrin placebo)

Notable Outcomes of Zinc Supplementation

Increased Antioxidant Factors

• Serum Zinc levels significantly increased (p = 0.002).
• Glutathione (GSH) and total bilirubin (STB), both important antioxidants, rose after Zn intake.

Reduced Oxidative Stress Markers

• Copper-to-Zinc ratio decreased (p = 0.01), reducing oxidative burden.
• Homocysteine (hCys), a cardiovascular risk factor, dropped (p = 0.000).
• Catalase (CAT) activity decreased, suggesting a shift in oxidative balance.

Clinical Implications

Zinc supplementation may serve as a protective strategy against oxidative stress in HD patients.
Lower homocysteine levels may reduce cardiovascular risks in end-stage renal disease (ESRD) patients.
Increased glutathione and bilirubin levels contribute to improved antioxidant defenses.

How Zinc Affects Oxidative Stress in Hemodialysis

Zinc plays a pivotal role in multiple biological functions:
Acts as an antioxidant by neutralizing free radicals.
Supports glutathione synthesis, a key detoxifying agent.
Reduces homocysteine levels, lowering cardiovascular risks.

Future Research & Considerations

While the findings are promising, the study acknowledges limitations, including a small sample size and the need for larger trials focusing on Zn-deficient patients. Individualized supplementation approaches should be explored to maximize benefits while minimizing risks.

Read the Full Study

Explore the full research article at https://doi.org/10.29328/journal.jcn.1001116

For more groundbreaking nephrology research, visit Journal of Clinical Nephrology.

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