The Battle Between Plants and Viruses: Antiviral RNAi Defense vs. Viral Suppression

Understanding RNAi in Plants

  • RNAi is a critical defense mechanism that enables plants to target and degrade viral RNA.
  • Dicer-like (DCL) proteins process viral double-stranded RNA into small interfering RNAs (siRNAs).
  • These siRNAs, along with Argonaute (AGO) proteins, degrade viral RNA, preventing replication.

How Viruses Suppress RNAi

  • Viruses encode RNAi suppressors (VSRs) to counteract plant defenses.
  • Some VSRs bind to siRNAs, blocking their function, while others disrupt AGO proteins.
  • Example: The P15 suppressor of Peanut Clump Virus selectively binds 22-nt siRNAs to prevent systemic antiviral response.

Broader Implications for Plant Immunity

  • The American Phytopathological Society (APS) emphasizes the significance of plant RNAi research in developing virus-resistant crops.
  • Researchers are exploring genetic modifications that enhance RNAi efficiency to boost plant immunity.

Strategic Link Placement

Future Research Directions

  • Investigating plant microRNAs (miRNAs) that contribute to viral resistance.
  • Understanding how systemic acquired resistance (SAR) complements RNAi in plant immunity.

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