Update on the Clinical Applications of Mesenchymal Stem Cells: Advancements and Future Directions


Introduction: Mesenchymal stem cells (MSCs) are multipotent stromal cells with regenerative, anti-inflammatory, and immunomodulatory properties. Their ability to treat various diseases, including autoimmune disorders, cardiovascular diseases, and infections, has gained widespread interest in the medical community. This article explores the latest advancements in MSC therapy and their clinical applications.


Main Content Sections:

  • Key Findings on MSC Therapy:
    • MSCs can be derived from various sources, including bone marrow, adipose tissue, and umbilical cord blood.
    • Their clinical applications include autoimmune disease treatment, hematopoietic stem cell transplantation, regenerative medicine, and infection control.
    • MSC-derived extracellular vesicles and exosomes replicate many therapeutic effects of parent stem cells.
  • Factors Affecting MSC Efficacy:
    • Donor age, biological source, and administration route impact therapeutic outcomes.
    • Genetic engineering enhances clinical efficacy and reduces adverse effects.
    • Challenges remain in standardizing MSC therapy protocols and regulatory approval.

Integration of External Medical Sources: The International Society for Stem Cell Research (ISSCR) supports the use of MSCs in regenerative medicine, highlighting their potential in treating inflammatory diseases and enhancing tissue repair.


Key References and Useful Links:



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