Oncocytic Papillary Cystadenoma of the Larynx:A Rare Benign Tumor

Introduction: Oncocytic papillary cystadenoma (OPC) is a rare and intriguing benign tumor of the laryngeal seromucinous glands. Typically affecting patients in their sixth or seventh decade of life, this condition presents diagnostic and therapeutic challenges. Learn more about cutting-edge research in this field by visiting ClinMed Case Reports Journal.

Understanding Oncocytic Papillary Cystadenoma: OPC of the larynx is an uncommon lesion classified among laryngeal salivary gland tumors. While its exact cause remains unclear, contributing factors may include:

• A history of chronic inflammation
• Prolonged vocal stress
• Possible smoking-related changes

The lesion predominantly appears in the supraglottic region of the larynx and is often misdiagnosed as a simple cyst or another benign mass.

Case Summary: A 72-year-old woman presented with a mass in her right laryngeal ventricle, initially diagnosed as a cyst. Despite unremarkable blood test and chest radiograph results, her medical history indicated chronic laryngeal inflammation diagnosed 15 months earlier. The lesion was successfully removed via direct laryngoscopy under general anesthesia, and the patient recovered well post-surgery.

Histological analysis confirmed the diagnosis of oncocytic papillary cystadenoma, revealing multiple well-defined cysts lined by oncocytic columnar cells with eosinophilic cytoplasm and palisading cigar-shaped nuclei. The absence of lymphoid stroma helped differentiate OPC from Warthin’s tumor.

Diagnosis and Treatment Considerations:

• Diagnostic Techniques:
  • Laryngoscopy for lesion visualization
  • Histopathological examination for confirmation
  • Differential diagnosis to distinguish from Warthin’s tumor or oncocytic metaplasia
• Treatment Approaches:
  • Surgical excision via direct laryngoscopy
  • CO2 laser excision in some cases
  • Close follow-up for recurrence monitoring

Broader Implications in Laryngeal Tumors: The American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) highlights the importance of early detection and histological confirmation in managing benign laryngeal tumors. This approach ensures proper differentiation from malignant lesions and prevents unnecessary invasive treatments.

Access the Full Study: For an in-depth analysis, read the complete research article at https://doi.org/10.29328/journal.acr.1001048.

Further Reading & Related Studies:

• Explore more case reports on laryngeal tumors at ClinMed Case Reports Journal
• Learn about oncocytic tumors and histopathological findings in related conditions

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