Fatal Acute Necrotizing Pancreatitis in a 15-Year Old Boy A Potential MIS-C Case

Introduction: Acute necrotizing pancreatitis is an uncommon yet life-threatening condition in children. In this case report, we explore the tragic case of a 15-year-old boy who developed severe pancreatitis, raising concerns about a potential link to Multisystem Inflammatory Syndrome in Children (MIS-C) associated with COVID-19. Visit https://www.clinmedcasereportsjournal.com/acr for more groundbreaking research in this field.

Case Overview:

• A 15-year-old boy presented with severe abdominal pain, fever, and systemic inflammatory response.
• Initial assessments revealed high serum amylase and lipase levels, fulfilling criteria for acute pancreatitis.
• Imaging studies confirmed necrotizing pancreatitis with peripancreatic fluid collection.
• The absence of known risk factors such as trauma, medication history, or bile duct disease led to further investigation.

Potential Link to MIS-C:

• The patient exhibited multiple organ involvement, including hematuria and gastrointestinal symptoms.
• Elevated inflammatory markers such as procalcitonin, fibrinogen, and Pro-BNP supported the suspicion of MIS-C.
• Despite negative COVID-19 PCR and serology results, the case fulfilled MIS-C criteria based on RCPCH and CPSP guidelines.

Treatment & Challenges:

• Conservative management, including antibiotics, IV fluids, and close monitoring, was initiated.
• Immunomodulatory therapy with IVIG and corticosteroids was administered based on MIS-C suspicion.
• The patient underwent multiple surgical interventions due to persistent symptoms and complications.
• Unfortunately, despite aggressive treatment, the patient developed acute respiratory distress syndrome (ARDS) and succumbed after one month of hospitalization.

Broader Implications: The American College of Rheumatology (ACR) emphasizes the importance of early recognition and treatment of MIS-C to prevent severe complications. This case underscores the potential severity of COVID-19-related inflammatory syndromes and the need for further research into its diverse clinical manifestations.

Full Study Access: Read the full study at https://doi.org/10.29328/journal.acr.1001056.

Related Research:

• Explore similar cases in our journal archive: [Link to related category/articles]
• Learn more about pediatric inflammatory conditions: [Link to internal article]

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