Age-Related Changes in Cell Yield and Viability of Feline Adipose Tissue-Derived Mesenchymal Stem Cells (fAD-MSCs)

Introduction

The field of regenerative medicine has revolutionized biomedical research, with stem cell biology playing a critical role in tissue engineering and therapeutic applications. Among various stem cell sources, adipose tissue-derived mesenchymal stem cells (AD-MSCs) are highly valued for their accessibility, high yield, and regenerative potential. This blog explores a recent study on age-related changes in cell yield and viability of feline Adipose Tissue-Derived Mesenchymal Stem Cells (fAD-MSCs).

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Study Overview

A study conducted by Shazia Nissar et al. investigated the effects of age on cell yield and viability of fAD-MSCs. The researchers collected omental adipose tissue samples from felines of different age groups and processed them using enzymatic digestion to isolate mesenchymal stem cells.

Key Findings

• The highest cell yield was observed in younger cats (7-9 months old), indicating a strong potential for regenerative medicine applications.
• Viability rates were significantly higher in younger groups, gradually decreasing with age.
• The study confirmed that stem cell proliferation rate declines as the animal ages, making younger-derived stem cells a better candidate for therapeutic applications.

Implications for Regenerative Medicine

According to The American Society of Gene & Cell Therapy (ASGCT), younger mesenchymal stem cells have greater differentiation capacity and regenerative abilities, making them more effective for therapeutic interventions.

DOI and Further Reading

For an in-depth analysis, read the full study at https://doi.org/10.29328/journal.jsctt.1001024.

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