Fetal Ductal Constriction Due to Maternal Metamizole Intake: A Rare but Significant Concern

Introduction: Fetal ductal constriction is a rare but critical condition that can have significant consequences for neonatal health. A recent case study highlights the potential link between maternal consumption of metamizole, a widely used analgesic, and premature closure of the ductus arteriosus in utero. Understanding such risks is vital for improving maternal-fetal care. Visit https://www.clinmedcasereportsjournal.org/acr for more groundbreaking research in this field.

Understanding Fetal Ductal Constriction:

• The ductus arteriosus is a vital fetal blood vessel that directs blood away from the lungs before birth.
• Normally, it closes after birth, but premature closure in utero can lead to complications such as right ventricular hypertrophy and pulmonary hypertension.
• This condition is often linked to maternal use of nonsteroidal anti-inflammatory drugs (NSAIDs), including ibuprofen and indomethacin.

Case Report Summary: A 20-year-old pregnant woman, with a history of high-risk pregnancy complications, was diagnosed with fetal ductal constriction at 37 weeks of gestation. Key findings included:

• Medications taken: Metamizole (575 mg every 8 hours) for recurrent renal colic pain.
• Ultrasound results: Delayed intrauterine growth, oligohydramnios, and significant right ventricular hypertrophy.
• Delivery outcome: Cesarean section performed due to fetal concerns; the newborn had mild respiratory distress but recovered well within 48 hours.

Read the full study at https://doi.org/10.29328/journal.acr.1001077.

Medical Perspectives on Metamizole Use During Pregnancy: The American College of Obstetricians and Gynecologists (ACOG) advises against the use of NSAIDs in the third trimester due to potential fetal risks. Metamizole, though commonly used in several countries, lacks well-defined safety guidelines for pregnancy. Studies suggest:

• It may contribute to premature ductal closure similar to other NSAIDs.
• Associated risks include oligohydramnios and potential fetal cardiovascular complications.

Clinical Implications and Recommendations:

• Physicians should exercise caution when prescribing pain relievers to pregnant women.
• Alternative pain management strategies should be explored to prevent fetal cardiovascular complications.
• Routine fetal echocardiography may be beneficial in high-risk pregnancies where NSAIDs have been used.

Conclusion & Call to Action: This case underscores the importance of monitoring medication use during pregnancy to prevent fetal cardiovascular complications. Further research is needed to establish safer analgesic options for expectant mothers.

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