Hepatic Pseudolymphoma Mimicking Neoplasia in Primary Biliary Cholangitis: A Rare Case Report

Introduction: The detection of liver nodules in patients with chronic liver disease often raises concerns about malignancy. In a recent case, a hepatic pseudolymphoma (HPL) was identified in a patient with primary biliary cholangitis (PBC), demonstrating how this benign condition can mimic liver cancer. Understanding such rare occurrences is crucial for accurate diagnosis and patient management. Visit ClinMed Case Reports Journal for more groundbreaking research in this field.

Understanding Hepatic Pseudolymphoma (HPL): HPL, also known as reactive lymphoid hyperplasia, is a rare benign lesion characterized by polyclonal lymphocyte proliferation. Though it has been reported in various organs, its presence in the liver remains uncommon. This condition is often associated with immune-mediated inflammation, as seen in PBC.

Case Summary:

• Patient: A 63-year-old woman with a history of PBC.
• Symptoms: Incidentally detected liver nodule during routine imaging.
• Imaging Findings:
  • Hypoechoic liver lesion (16mm) with no arterial enhancement on CT.
  • MRI revealed T2 hyperintensity and diffusion restriction.
• Diagnosis Approach:
  • Given the indistinct radiological features, a histopathological examination was performed.
  • Biopsy confirmed HPL through immunohistochemistry, revealing polyclonal lymphoid proliferation with no malignant transformation.

Clinical Implications and External Insights: The American College of Radiology (ACR) emphasizes the importance of ensuring patient access to advanced imaging techniques for accurate diagnosis of liver abnormalities. As imaging alone may not differentiate between malignant and benign liver lesions, histological examination remains crucial in cases like HPL.

Further Reading and Resources:

• Read the full study at https://doi.org/10.29328/journal.acr.1001115.
• Learn more about related hepatological conditions in our liver disease section.
• A detailed analysis can be found in our main journal article.

Conclusion & Call-to-Action: HPL, though rare, should be considered in patients with chronic liver disease presenting with liver nodules. Accurate diagnosis via biopsy helps prevent unnecessary interventions and ensures optimal patient care. Explore more studies at ClinMed Case Reports Journal and share your thoughts in the comments below!

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