Understanding Jaw Subluxation as a Complication of Tardive Dyskinesia

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Case Summary: A Rare but Serious Complication

A recent study reported a case of an 80-year-old woman with TD who developed jaw subluxation after prolonged use of multiple antipsychotic medications, including haloperidol, brexpiprazole, risperidone, and olanzapine. The patient, initially treated for psychosis and paranoia, experienced severe motor symptoms, including tremors and dysarthria, before developing jaw dislocation.

Clinical Implications and Management

  • TD is often irreversible and worsens over time if not properly managed.
  • Risk Factors: Long-term antipsychotic use, particularly in elderly patients, increases the likelihood of developing TD and associated complications.
  • Treatment Approaches:
    • Discontinuation or modification of antipsychotic therapy.
    • Introduction of alternative medications such as VMAT2 inhibitors (tetrabenazine, deutetrabenazine, valbenazine) to help manage TD symptoms.
    • Emergency intervention for jaw subluxation, including manual reduction procedures and pain management strategies.

Further Reading and Resources: For a detailed analysis, read the full study at https://doi.org/10.29328/journal.acr.1001112. Additionally, explore related topics in our journal archives for more insights into movement disorders and their management.

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