Unveiling the Antimicrobial and Antioxidant Power of Streptomyces sp. PERM2

Introduction: Streptomyces species have long been recognized for their ability to produce bioactive secondary metabolites with diverse medical applications. A recent study has highlighted the antimicrobial and antioxidant properties of ethyl acetate extract from Streptomyces sp. PERM2, showcasing its potential as an alternative to combat multidrug-resistant pathogens.

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Key Findings:

• The ethyl acetate extract demonstrated significant antimicrobial activity against Gram-positive and Gram-negative bacteria, including Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa.
• It inhibited fungal pathogens such as Pythium myriotylum and Fusarium solani with notable minimum fungicidal concentrations (MFCs).
• The study identified 112 volatile organic compounds (VOCs) through GC-MS, with key bioactive compounds such as 9,12-octadecadienoic acid (antioxidant), tridecyl trifluoroacetate (antibiofilm), and 1-(+)-ascorbic acid 2,6-dihexadecanoate (anti-inflammatory and wound healing).
• The extract was shown to disrupt bacterial cell wall synthesis and inhibit ATPase proton pumps, contributing to its antimicrobial efficacy.
• LC-MS/MS analysis identified 3,30-di-methyl ellagic acid, known for its antioxidant, antibacterial, and cytoprotective properties.

Broader Implications in Medical Research: According to the World Health Organization (WHO), the increasing prevalence of antimicrobial resistance underscores the need for novel bioactive compounds. The findings from this study highlight the potential of Streptomyces metabolites as a promising source of new antimicrobial agents.

Read the Full Study: Access the complete research at https://doi.org/10.29328/journal.acr.1001113.

Further Reading & Related Research:

• Explore more microbiological studies on ClinMed Case Reports.
• Check out related research on antimicrobial resistance in our Microbiology Category.

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