C-Reactive Protein and Ventricular Repolarization

Introduction: An increasing body of research highlights the impact of inflammation on heart health, particularly among individuals with metabolic syndrome (MetS). A recent study published in the Journal of Cardiology and Cardiovascular Medicine explores how elevated C-reactive protein (CRP) levels correlate with changes in ventricular repolarization, potentially increasing the risk of cardiac events.

Key Findings from the Study:

  • Patients with MetS and CRP levels above 3mg/L had significantly higher QTc dispersion than those with lower CRP levels.
  • Prolonged QTc dispersion was found in 51.4% of high-CRP patients compared to 32.9% of those with lower CRP levels.
  • A higher prevalence of Tpeak-Tend dispersion was also observed in high-CRP patients, suggesting increased arrhythmogenic risk.

Further Reading and Resources The study, conducted across multiple health centers, analyzed data from 200 MetS patients, assessing their QT and QTc intervals using a 12-lead ECG. Findings confirmed a significant association between high CRP levels and prolonged repolarization markers, which could predispose patients to arrhythmias and sudden cardiac death.

Further Reading & Related Studies:

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