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Comparing Oral Clindamycin and Metronidazole for Bacterial Vaginosis in Pregnancy Which Is More Effective

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by

Vishnu
in

Introduction

Bacterial vaginosis (BV) is a common yet often overlooked concern during pregnancy, especially in sub-Saharan Africa. A recent clinical study conducted at the University of Port Harcourt Teaching Hospital offers new insight into the comparative effectiveness of oral Clindamycin and oral Metronidazole for treating BV in pregnant Black women.
Visit https://www.obstetricgynecoljournal.com for more groundbreaking research in obstetrics and gynecology.

Study Highlights Oral Clindamycin vs. Metronidazole

  • Study Location: University of Port Harcourt Teaching Hospital, Nigeria
  • Sample Size: 136 BV-positive pregnant women
  • Treatment Groups:
    • Oral Metronidazole (400 mg three times daily)
    • Oral Clindamycin (300 mg twice daily)
  • Duration: 7 days
  • Follow-up: Until one week post-delivery

Key Findings

  • Cure Rates:
    • Oral Clindamycin: 89.6%
    • Oral Metronidazole: 87%
      (No statistically significant difference; p = 0.639)
  • Pregnancy Outcomes:
    • Preterm Delivery: 7.5% in both groups
    • Pre labour Rupture of Membranes: Slightly higher in Metronidazole group
    • Mean Gestational Age: ~38.68 weeks
    • Low Birth Weight: 6.7% overall
    • Perinatal Deaths: 2 (Metronidazole group only, not statistically significant)

Broader Implications in Maternal Care

The American College of Obstetricians and Gynecologists (ACOG) and Centers for Disease Control and Prevention (CDC) support the use of both drugs for BV treatment in pregnancy. This study supports those guidelines by proving both treatments result in comparable efficacy and similar pregnancy outcomes in a low-risk, asymptomatic population.

Full Access to the Research Article

Read the complete study
https://doi.org/10.29328/journal.cjog.1001040

Why This Study Matters

  • BV is prevalent in African populations and often asymptomatic.
  • Effective treatment during pregnancy reduces risks of preterm birth, low birth weight, and perinatal infections.
  • Provides a real-world, evidence-based comparison of widely used antibiotics.
  • Validates the interchangeability of oral clindamycin and oral metronidazole in clinical obstetric practice.

Explore More Research

Visit https://www.obstetricgynecoljournal.com to discover the latest in gynecologic and obstetric advancements. A detailed analysis of similar studies is also available in our Research Articles section.

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