How Dysmenorrhea Treatments May Be Harming Liver and Kidney Health A Molecular Insight

Introduction

Dysmenorrhea, a prevalent menstrual disorder affecting up to 90% of women globally, is more than just monthly painit might be silently affecting liver and kidney health. A recent study from Cameroon provides compelling molecular evidence linking prolonged dysmenorrhea treatment with signs of hepatotoxicity and nephrotoxicity.

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Molecular Markers Reveal Hidden Risks

Researchers at the University of Dschang analyzed blood and urine samples from 191 female students, revealing that

• Students with dysmenorrhea lasting over 9 years had significantly higher levels of liver enzymes ALT and AST—clear signs of potential liver stress.
• Long-term NSAID use correlated with reduced creatinine clearance, indicating impaired kidney function.
• Anti-inflammatory drugs (like Ibuprofen and Diclofenac) led to worse renal performance than analgesics alone.

Read the full study at: https://doi.org/10.29328/journal.cjog.1001042

Understanding the Biological Mechanism

Dysmenorrhea triggers inflammation and oxidative stress due to prostaglandin overproduction. These effects are worsened by:

• Repeated medication use, even if short-term
• Reactive oxygen species (ROS) that damage liver and kidney cells
• Prolonged exposure to NSAIDs, disrupting renal blood flow and glomerular function

According to the American College of Obstetricians and Gynecologists (ACOG), managing dysmenorrhea requires balancing pain relief with long term health preservation ACOG Website.

Who s Most at Risk

This study found that the following groups are particularly vulnerable:

• Those using NSAIDs for more than 9 years
• Those with chronic primary dysmenorrhea
• Those using combined analgesic and anti-inflammatory therapies

Internal data from the study showed no significant damage in those using Paracetamol alone, but caution is still advised with prolonged usage.

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Clinical Implications and Next Steps

The results stress the importance of

• Routine liver and kidney function tests for chronic dysmenorrhea patients
• Educating young women on the safe use of pain medications
• Exploring non-pharmacological interventions such as lifestyle and dietary changes

A detailed analysis can be found in our main journal article.

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