How Endometrial Thickness Influences IVF Success A Breakthrough in Frozen Embryo Transfer

Introduction

When it comes to successful assisted reproduction, the endometrial environment plays a crucial role. A recent prospective study published in the Clinical Journal of Obstetrics and Gynecology sheds new light on how endometrial thickness affects outcomes in frozen-thawed embryo transfer (FET) cycles.

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Study Overview

Researchers from ARC International Fertility Center and Saveetha University conducted a focused investigation on 69 women undergoing FET. The aim? To evaluate whether endometrial thickness, visualized through ultrasound, could predict implantation, early miscarriage, and ongoing pregnancy.

Key Findings: The Role of Endometrial Thickness

• Patients with endometrial thickness > 6 mm had better ongoing pregnancy rates.
• Clinical pregnancy rate was 47.83% overall, but significantly higher among women with a thicker endometrium.
• Early miscarriage was more frequent in women with a thinner endometrium (< 6 mm).

Read the full study at https://doi.org/10.29328/journal.cjog.1001066

Why Endometrial Thickness Matters

Endometrial thickness reflects uterine receptivity, and its ideal measurement is a strong predictor for embryo implantation. In this study:

• Endometrial grading using ultrasound proved useful in synchronizing Day 5 embryo transfer with the Window of Implantation (WOI).
• Thin endometrium, while occasionally successful, had more association with implantation failure and early pregnancy loss.
• Supplementation with HCG, estrogen, and aspirin were used to improve endometrial quality and receptivity.

The American Society for Reproductive Medicine (ASRM) emphasizes the importance of assessing endometrial receptivity to optimize IVF outcomes and recommends individualized treatment strategies for thin endometrium patients.

Clinical Implications

This research suggests clinicians should:

• Closely monitor ultrasound patterns and vascularization.
• Consider endometrial enhancement protocols in women with thin lining.
• Be cautious but not dismissiveimplantation is still possible in some patients with thin endometrium.

A detailed analysis can be found in our main journal article.

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Takeaways

• Endometrial thickness > 6 mm increases chances of ongoing pregnancy in FET cycles.
• Ultrasound assessment remains a cost-effective, non-invasive predictor.
• Biophysical endometrial profiles are important for treatment personalization.

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