Improving Outcomes in Frozen Embryo Transfers The Role of Dydrogesterone Supplementation

Introduction

Frozen-thawed embryo transfers (FET) are now a cornerstone in assisted reproductive technologies (ART), but achieving optimal pregnancy outcomes can be challenging, especially when progesterone (P) levels are low. Recent research highlights a promising intervention: the addition of dydrogesterone to vaginal progesterone, alongside embryo transfer postponement. Visit Obstetric and Gynecology Journal for more groundbreaking research in reproductive health.

Addressing Low Progesterone in FET

A new study published in Clinical Journal of Obstetrics and Gynecology evaluated whether adding dydrogesterone (DYD) to vaginal micronized progesterone (VMP), coupled with delaying embryo transfer by one day, could improve outcomes in hormonally substituted FET cycles. The research focused on women whose initial serum progesterone levels were below the critical threshold of 11 ng/mL.

• Participants: 376 cycles analyzed
• Intervention: DYD 30 mg daily added when P < 11 ng/mL, transfer postponed by one day
• Primary Endpoint: Live birth rate (LBR) comparison

Key Findings: Dydrogesterone and Timing Matter

The results were remarkable:

• Live birth rates were similar between those with low progesterone levels who received dydrogesterone and postponed transfers (26.1%) and those with sufficient progesterone and “in-phase” transfers (27.3%).
• Birth weight was significantly higher among singletons born from the dydrogesterone group.
• Postponing embryo transfer by one day provided crucial time for hormonal adjustment, enhancing endometrial receptivity.

Read the full study at https://doi.org/10.29328/journal.cjog.1001103

Progesterone’s Role in ART Success

The American Society for Reproductive Medicine (ASRM) emphasizes that adequate luteal phase support is critical in ART cycles. Low progesterone levels have been repeatedly linked with reduced implantation and live birth rates across multiple studies. Optimizing progesterone supplementation strategies, like the addition of dydrogesterone, offers a patient-friendly and effective alternative to more invasive methods.

How Clinics Can Apply These Findings

Clinicians managing FET cycles should consider:

• Early progesterone monitoring after initiating hormonal therapy.
• Individualized supplementation with dydrogesterone in cases of low serum P levels.
• Flexibility in transfer timing based on hormonal readiness rather than rigid scheduling.

This tailored approach not only improves outcomes but also reduces the risk of cycle cancellation, a significant emotional and financial burden for patients.

Explore More on Frozen Embryo Transfers

A detailed analysis can be found in our main journal article. To discover more advancements in reproductive medicine, visit Obstetric and Gynecology Journal today.

Conclusion

The study reinforces that strategically adjusting progesterone support and transfer timing can greatly impact FET success. Incorporating dydrogesterone supplementation offers a simple, safe, and effective method to address low progesterone levels, ensuring more hopeful outcomes for aspiring parents.

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