Pulmonary Thromboembolism in Pregnancy A Case Linked to Latent Lupus

Introduction

Pregnancy can sometimes unmask hidden health conditions, leading to lifethreatening complications. A recent case study titled “Journey with a 21 weeks primi with acute massive pulmonary thromboembolism secondary to possible ‘Latent Lupus’: an audacious ride” highlights how acute pulmonary embolism (PE) can be the first sign of an underlying autoimmune disorder.
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Main Content

This case involved a 20-year-old woman, 21 weeks into her first pregnancy, who presented with sudden chest pain, shortness of breath, and hemodynamic instability. Despite the absence of traditional risk factors for venous thromboembolism (VTE), she was diagnosed with acute massive pulmonary embolism. Immediate intervention using streptokinase led to remarkable recovery for both mother and fetus.

A detailed analysis can be found in our main journal article.

Key Findings

• Diagnosis Challenges: Diagnosing PE during pregnancy remains difficult due to reluctance to expose the fetus to ionizing radiation.
• Treatment Success: Thrombolysis with streptokinase was chosen considering clinical deterioration, leading to stabilization without maternal or fetal bleeding complications.
• Latent Lupus Connection: Autoimmune tests revealed a high ANA titer, suggesting “latent lupus,” though full-blown systemic lupus erythematosus (SLE) criteria were not met.

Read the full study at https://doi.org/10.29328/journal.cjog.1001102.

Broader Medical Insights

Pulmonary embolism is a leading cause of maternal mortality worldwide. According to the American College of Obstetricians and Gynecologists (ACOG), early suspicion and prompt treatment of VTE are critical, especially in pregnant women exhibiting unexplained symptoms.

Additionally, understanding the impact of autoimmune disorders like SLE in pregnancy is essential, as these can increase VTE risk dramatically.

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