Unraveling the Mystery Primary Ovarian Lymphoma Presenting as Fever of Unknown Origin

Introduction

Primary ovarian lymphoma is a rare and often misdiagnosed condition due to its unusual presentation. A groundbreaking case report published in the Clinical Journal of Obstetrics and Gynecology sheds light on a unique instance where a 53-year-old woman presented with Fever of Unknown Origin (FUO), eventually diagnosed as ovarian B-cell lymphoma. Visit https://www.obstetricgynecoljournal.com for more groundbreaking research in this field.

A Rare and Challenging Diagnosis

Ovarian lymphoma is an uncommon diagnosis, accounting for only 0.5% of all non-Hodgkin’s lymphomas and 1.5% of all ovarian neoplasms. In most cases, pelvic pain or a mass leads to suspicion, but FUO as a presenting symptom is exceedingly rare.

• The patient initially presented with general malaise, high fever, and left renal angle discomfort.
• Despite broad-spectrum antibiotics, symptoms persisted, prompting further imaging studies.
• A pelvic ultrasound and CT scan revealed a complex left ovarian mass.

Read the full study at https://doi.org/10.29328/journal.cjog.1001116.

Diagnosis and Treatment

The unusual persistence of fever led clinicians to perform a diagnostic laparoscopy. A friable ovarian mass necessitated conversion to laparotomy and subsequent left salpingo-oophorectomy.

• Pathology confirmed B-cell lymphoma localized to the ovary.
• Postoperative recovery was rapid, and no further systemic disease was found through PET and CT scans.
• The multidisciplinary team approach involving gynecology and oncology specialists ensured comprehensive care.

The American Society of Clinical Oncology (ASCO) emphasizes the importance of early diagnosis and a multidisciplinary approach in managing rare lymphomas to improve patient outcomes.

Clinical Implications

This case is believed to be the first reported instance of primary ovarian lymphoma presenting primarily as FUO. Clinicians should consider ovarian lymphoma in the differential diagnosis for women with unexplained fever and pelvic masses to avoid delayed interventions and unnecessary treatments.

Key takeaways:

• Maintain a high index of suspicion for rare causes of FUO.
• Utilize advanced imaging and timely surgical interventions.
• Multidisciplinary collaboration is crucial for accurate diagnosis and management.

Explore related gynecologic case reports at https://www.obstetricgynecoljournal.com.

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