SARS CoV 2 Infection Found Not to Impact Ovarian Reserve in Women Undergoing Assisted Reproduction

Understanding the Study Findings
The research, conducted across multiple centers, evaluated whether women who recovered from COVID-19 experienced changes in ovarian reserve by measuring Anti-Müllerian Hormone (AMH) levels. Here are the key highlights:

  • Participants: 46 women with previous AMH measurements and confirmed SARS-CoV-2 IgG positivity.
  • Grouping: Divided into low responders (AMH < 1 ng/ml) and normal-high responders (AMH ≥ 1 ng/ml).
  • Main Result: No significant difference in AMH levels pre- and post COVID-19 infection (1.73 ng/ml vs. 1.61 ng/ml).
  • Subgroup Analysis:
    • Normal-high responders: Slight AMH decline (4.6 ng/ml to 3.1 ng/ml).
    • Low responders: Minimal change (0.8 ng/ml to 0.7 ng/ml).

Impact on Assisted Reproductive Treatments
Further assessments showed that key parameters like:

  • Gonadotropin dosage
  • Days of ovarian stimulation
  • Retrieved oocytes
  • Fertilization rates

remained consistent before and after COVID-19 infection. This offers much-needed reassurance to patients undergoing fertility treatments.

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