Twins vs Singletons Surprising Insights into Neonatal Mortality at 34 37 Weeks

Introduction

Comparing Neonatal Mortality in Twins and Singletons

A comprehensive analysis of over 579,000 births between 2018 and 2020 revealed that:

  • Neonatal mortality was lower in twins than in singletons at 34–37 weeks.
  • Singleton neonates experienced a higher death rate in the delivery room and after NICU admission.
  • Twins had more frequent antenatal corticosteroid administration, potentially contributing to better outcomes.

Key Findings

  • Overall mortality rate post-admission: 1.85% for singletons vs. 1.06% for twins.
  • Delivery room death rate: 1.43 per 1000 births (singletons) vs. 0.77 per 1000 (twins).
  • Use of C-sections: 95% in twins vs. 64% in singletons.

Factors Influencing Mortality Outcomes

Maternal and Neonatal Influences

  • Birth weight and gestational age remain critical predictors.
  • Very low birth weight neonates had mortality odds ratios of 6.91 overall, with twins facing higher risks than singletons in this category.
  • Consanguinity, lack of childbirth preparation classes, and previous pregnancies emerged as significant mortality risk enhancers.

Medical Intervention

  • Antenatal corticosteroids were more commonly administered in twin pregnancies (28.4% vs. 16.8%).
  • Despite previous conflicting reports, this study indicates that twins benefit from earlier interventions and specialized care protocols.

External Perspective on Neonatal Standards

Call to Action

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