Introduction:
Endometrial cancer remains one of the most prevalent gynecological malignancies, with increasing incidence globally. A recent study explores the factors contributing to loco-regional recurrences (LRR) in patients treated for endometrial cancer. By identifying predictive markers for LRR, this study aims to optimize treatment strategies and improve patient outcomes. Visit https://www.obstetricgynecoljournal.com for more groundbreaking research in this field.
Study Overview
The research examines data from 214 patients diagnosed with endometrial cancer between 2005 and 2012 at Salah Azaiz Institute, Tunisia. The study investigates the pattern of failure in endometrial cancer patients and identifies key factors associated with loco-regional recurrence (LRR).
Key Findings
- Survival Rates: The 5-year overall survival rate was 78.1%, and the 5-year progression-free survival rate was 80.1%.
- Sites of Relapse: Pelvic relapse was the most common site of recurrence, followed by vaginal and retro-peritoneal relapses.
- Predictive Factors: The study identified several significant predictors of LRR, including FIGO stage, tumor grade, histologic type, lympho-vascular space invasion (LVSI), and treatment delays.
Impact of Treatment Delays
Patients whose adjuvant treatments were delayed by more than three months experienced a higher incidence of LRR. This highlights the importance of timely adjuvant therapy to reduce the risk of recurrence.
Significance of FIGO Stage and LVSI
Multivariate analysis revealed that FIGO stage and LVSI were independent predictive factors for LRR, stressing the need for personalized treatment plans based on these markers.
Integration of External Medical Sources
The American College of Obstetricians and Gynecologists (ACOG) emphasizes the significance of early-stage detection and individualized treatment plans in improving the prognosis for endometrial cancer patients.
Read the full study at https://doi.org/10.29328/journal.cjog.1001169.
Further Reading and Resources
A detailed analysis can be found in our main journal article here.
Call-to-Action
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