Daily Tacrolimus Dosing Reduces PostTransplant Risks Insights from a Renal Transplant Study

Introduction

Improving medication adherence in renal transplant patients is crucial to enhancing long-term graft survival. A recent study sheds light on the comparative benefits of once-daily tacrolimus (extended-release) over conventional twice-daily regimens. Conducted at Suguna Hospital, Bangalore, this research highlights how simplified dosing can significantly reduce infection rates and post-transplant diabetes mellitus (PTDM) among kidney transplant recipients.
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Study Overview and Key Findings

• Study Design:
  A single-center, retrospective analysis comparing 24 patients on once-daily (OD) tacrolimus versus 24 on twice-daily (BD) tacrolimus over a two-year period post-renal transplantation.
• Patient Profile:
  Both groups had similar demographics in terms of age, weight, gender, donor type, and baseline renal condition.
• Findings:
  • Adherence & Efficacy: No significant difference in creatinine levels, graft function, or survival between OD and BD groups.
  • Infection Rates: OD group showed a drastic reduction in infections (4.17%) compared to the BD group (41.67%), p = 0.01.
  • PTDM Incidence: OD tacrolimus significantly lowered the risk of post-transplant diabetes (4.1% vs 20.83%, p = 0.17).
  • Tacrolimus Dosing: The average dose and trough levels remained stable in the OD group, challenging previous studies that recommended higher dosing for OD formulations.
• Safety Profile:
  Both regimens showed similar side effect profiles, with the OD group benefiting from more stable pharmacokinetics and fewer toxic surges.

Clinical Significance and Broader Impact

The American Society of Transplantation supports innovations that enhance medication adherence, especially in chronic transplant patients. Simplifying immunosuppressive regimenslike adopting once-daily tacrolimuscan lead to fewer complications and better long-term outcomes.

Access the Full Study

Read the full study at https://doi.org/10.29328/journal.ijcv.1001050

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