Validated HPLC-UV Method Ensures Accurate Determination of Amoxicillin Trihydrate in Capsules

Introduction

Ensuring the quality of antibiotics is critical in combating antimicrobial resistance and safeguarding public health. A recent study validated a costeffective and reliable HPLC-UV method for estimating amoxicillin trihydrate in capsule formulations, offering precision and accuracy in pharmaceutical quality control. This method plays a vital role in detecting counterfeit or substandard antibiotics, which can otherwise lead to treatment failure and resistance. Visit https://www.advancechemjournal.com/ for more groundbreaking research in this field.

Key Findings of the Study

• High Accuracy and Precision:
  • The validated HPLC-UV method showed excellent linearity (r² = 0.9998) across a range of 20–160 µg/ml.
  • Recovery rate was 100.6 ± 4%, confirming its accuracy and reliability.
• Sensitivity of the Method:
  • Limit of Detection (LOD): 1.57 µg/ml
  • Limit of Quantification (LOQ): 4.78 µg/ml
  • These values highlight the method’s capability to detect even small variations in drug content.
• Consistency Across Batches:
  • All amoxicillin samples tested from Rwanda’s retail pharmacies complied with pharmacopeia standards (90–120% of the labeled amount).
  • No counterfeit or substandard formulations were detected during the study period

Why This Matters for Public Health

Substandard and falsified medicines remain a global threat. According to the World Health Organization (WHO), poor-quality antibiotics contribute significantly to antimicrobial resistance, undermining effective treatment and leading to prolonged illness. Reliable analytical methods, such as the validated HPLC-UV approach, ensure medicine quality and protect patients.

Similarly, the U.S. Food and Drug Administration (FDA) emphasizes that validated analytical methods are essential to guarantee accurate, reproducible results in pharmaceutical testing. This aligns with international standards for patient safety and drug efficacy.

Accessing the Full Study

For researchers and practitioners interested in deeper insights, the complete study is available here:
Read the full study at https://doi.org/10.29328/journal.aac.1001014

A more detailed analysis is also published in our main journal article on Annals of Advances in Chemistry.

Applications of the Validated Method

• Routine Quality Control: Suitable for pharmaceutical laboratories monitoring drug potency.
• Counterfeit Drug Detection: Helps identify falsified medicines in local markets.
• Public Health Protection: Assures physicians and patients of safe and effective antibiotic therapies.

Call-to-Action

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