Pyogenic Liver Abscess Study Clinical Characteristics, Causes, and Treatment Outcomes in Hospitalized Patients

Introduction

Pyogenic Liver Abscess (PLA) is a serious infectious condition that primarily affects older and immunocompromised patients, with rising incidence due to improved diagnostic imaging and changing clinical risk factors. This research-based overview highlights a 10-year retrospective study that examines epidemiological characteristics, microbiology patterns, and treatment outcomes among patients presenting with PLA in a tertiary hospital setting. For more expert-reviewed gastroenterology research, visit https://www.gastrohepatoljournal.com/index.php/acgh.

Key Findings and Clinical Overview

The study analyzes 99 patients diagnosed with pyogenic liver abscess, revealing important trends in demographics, causes, symptoms, and therapeutic responses.

Major Study Highlights

• Most cases occurred in patients aged ≥65 years
• Biliary origin accounted for 40% of PLAs
• Other causes included:
  • Postsurgical complications (15%)
  • Intestinal origin (11%)
• Common symptoms included:
  • Fever
  • Abdominal pain
  • Nausea (more frequent in biliary PLA)

A detailed summary of the research findings can be accessed through the study
Read the full study at https://doi.org/10.29328/journal.acgh.1001005

Clinical Presentation and Diagnostic Trends

Age-Related and Etiological Differences (H2)

Patients with biliary PLA typically presented at an older age compared to intestinal PLA cases. Multiple abscesses and bilateral liver involvement were more frequently observed in biliary cases, while intestinal-origin abscesses were more commonly solitary and right-lobe dominant.

Key clinical markers included:

• Elevated ESR or CRP
• Cholestasis
• Leukocytosis

Microbiological confirmation was achieved in 63% of cases, with polymicrobial and aerobic gram-negative bacteria being common isolates.

Treatment Approaches and Outcomes

Management Strategies in PLA (H2)

All patients received systemic antibiotic therapy, with interventional procedures performed as required:

• Percutaneous drainage – 44.4% of cases
• Surgical drainage – 12.1% of cases

Patients with abscesses larger than 5 cm most frequently benefited from percutaneous drainage, reinforcing its role as a frontline therapeutic approach in appropriately selected cases.

A more detailed analysis can be found in our main journal article available within the study findings. In the broader medical context, organizations such as the American Association for the Study of Liver Diseases (AASLD) emphasize the importance of timely diagnosis and multidisciplinary management to reduce complications in liver-related infections.

Additionally, readers can continue exploring important gastroenterology focused research through the main portal at gastrohepatoljournal, where related topics and categories offer deeper clinical insights.

Broader Implications for Clinical Practice

Why These Findings Matter (H2)

This study reinforces key trends in PLA management:

• Higher prevalence in elderly populations
• Strong association with biliary pathology
• Importance of microbiological testing to guide therapy
• Comparable hospital stay between surgical and percutaneous approaches

Key Takeaways

• Early recognition improves outcomes
• Imaging-guided drainage remains critical for lesions >5 cm
• Elderly and immunocompromised patients require close monitoring
• Multidisciplinary care supports better recovery outcomes

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