Tag: #Nephrology

—

by

Introduction: Fibroblast Growth Factor 23 (FGF23) plays a crucial role in regulating phosphate metabolism and has been linked to cardiovascular complications in hemodialysis patients. A recent study published in the Journal of Clinical Nephrology explores the cleavage characteristics of FGF23 and its implications for chronic kidney disease (CKD) patients undergoing hemodialysis. Visit Journal of Clinical…

A Nephrology Department’s Experience

—

by

Introduction: Acute kidney injury (AKI) poses a significant global health challenge, impacting millions annually. While its incidence is well documented in developed regions, data from Africa, particularly the Maghreb, remain scarce. A recent study conducted in a Tunisian nephrology department offers valuable insights into the epidemiology and recovery of AKI patients. For more cutting-edge nephrology…

Assessing Steroid Response Through Resistivity and Pulsatility Indices

—

by

Introduction Nephrotic syndrome is a significant cause of chronic renal disease in children, often leading to long-term complications. This study evaluates resistivity and pulsatility indices in the interlobar arteries of the kidneys in pediatric nephrotic syndrome patients across different response groups. Using Doppler ultrasound, researchers analyzed how these indices correlate with steroid responsiveness, helping predict…

A Case of FSGS Diagnosis Through Kidney Biopsy

—

by

Introduction Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a prevalent genetic disorder, affecting approximately 6% of kidney failure cases. While proteinuria is uncommon in ADPKD, significant proteinuria warrants further investigation to exclude coexisting glomerular diseases. This case highlights the challenges and diagnostic approach to a patient with ADPKD and nephrotic-range proteinuria. Visit Journal of Clinical…

Rare Case of Dense Deposition Disease with Combined C3 and C4d Deposits in a Patient with MYH9 Mutation

—

by

Introduction Dense Deposition Disease (DDD) is a rare form of glomerulonephritis caused by dysregulation of the complement system. This case presents a young Emirati male diagnosed with DDD, featuring both C3 and C4d deposits—a rare occurrence. Adding to the uniqueness of this case, the patient also exhibited an MYH9 gene mutation. Case Summary A 26-year-old…

Eculizumab Failure and the Off-Label Use of Ravulizumab

—

by

Introduction Atypical Hemolytic Uremic Syndrome (aHUS) is a rare and severe disorder characterized by microangiopathic hemolytic anemia, thrombocytopenia, and renal failure. This case report highlights a catastrophic form of aHUS that was unresponsive to Eculizumab and required the off-label use of Ravulizumab, leading to successful hematologic recovery but progression to end-stage kidney disease. For more…

The Impact of Weight-Based Mycophenolate Mofetil Dosing

—

by

Introduction Mycophenolate Mofetil (MMF) plays a crucial role in post-kidney transplant immunosuppression. However, standard fixed dosing may not be ideal for all patients. A recent study evaluated a weight-based MMF dosing protocol to determine its safety and efficacy compared to a fixed-dose approach. Visit Clinical Nephrology Journal for more research updates in nephrology. Key Findings…

Ocular Pain and Intraocular Hypertension in Hemodialysis: A Hidden Risk for Kidney Patients”

—

by

Introduction: Patients undergoing hemodialysis often face a range of complications, but ocular issues, particularly intraocular hypertension (IOP), remain an underrecognized concern. A recent case report published in the Journal of Clinical Nephrology highlights a compelling case of resistant hypertension and severe ocular pain in a hemodialysis patient, ultimately linked to glaucoma. Understanding the impact of…

Unraveling Gitelman Syndrome: A Rare Yet Critical Cause of Electrolyte Imbalance”

—

by

Introduction Gitelman Syndrome (GS) is a rare genetic disorder affecting kidney electrolyte reabsorption, leading to persistent hypokalemia, hypomagnesemia, and metabolic alkalosis. Though often misdiagnosed, timely identification and management are crucial to prevent complications. Visit Clinical Nephrology Journal for more groundbreaking research in nephrology. Understanding Gitelman Syndrome GS is caused by mutations in the SLC12A3 gene,…

Rituximab in Adult Minimal Change Disease: A Breakthrough in Nephrotic Syndrome Treatment

—

by